Why ketamine? Because your brain can change.
Ketamine has been used safely in medicine for more than 50 years. Today, researchers are studying how it can help with depression, anxiety and PTSD.
A different way of working.
Most antidepressants adjust serotonin and can take weeks to help, if they help at all. Ketamine acts on glutamate, the brain's main signaling chemical.
Research suggests this can quickly encourage new connections between brain cells, known as neuroplasticity. Paired with guided preparation and reflection, many people find it easier to step out of old thought patterns.
The research behind at-home care.
2000 · First signal
A small clinical trial found that a single low dose of ketamine reduced depression symptoms within hours.1
2006 · Confirmed
A randomized, placebo-controlled trial in treatment-resistant depression found rapid improvement, many within a day.2
2022 · At home
A large study of at-home, telehealth-supported sublingual ketamine reported meaningful improvement in anxiety and depression for many patients.3
Safety comes first, every session.
How we keep you safe
- Every patient meets a licensed clinician on a 30-minute Zoom visit before any prescription
- Blood pressure check before each session with a monitor we ship to you
- A trusted adult nearby for your first sessions
- No driving or heavy machinery after a session until your clinician says it's safe
- Regular follow-ups and symptom tracking
Possible side effects
Common, short-lived effects include feeling detached or dreamlike, nausea, dizziness, blurred vision and a temporary rise in blood pressure. Your clinician will review risks with you and how to reduce them.
Who should not use at-home ketamine
At-home ketamine may not be appropriate if you have a history of psychosis or schizophrenia, bipolar I disorder, uncontrolled high blood pressure, certain heart or liver conditions, a current substance use disorder, or are pregnant or breastfeeding.
Off-label use
Ketamine is FDA-approved as an anesthetic. Prescribing it for depression, anxiety or PTSD is off-label, a common and legal practice when a licensed clinician believes it's appropriate.
- Berman RM, Cappiello A, Anand A, et al. Antidepressant effects of ketamine in depressed patients. Biological Psychiatry. 2000;47(4):351-354.
- Zarate CA Jr, Singh JB, Carlson PJ, et al. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Archives of General Psychiatry. 2006;63(8):856-864.
- Hull TD, Malgaroli M, Gazzaley A, et al. At-home, sublingual ketamine telehealth is a safe and effective treatment for moderate to severe anxiety and depression. Journal of Affective Disorders. 2022;314:59-67.